Evolution of the Human Genome

Our group is also interested in the evolution of the human genome from different perspectives. In collaboration with the group of Dr. Sarah Teichmann from the Molecular Biology Laboratory in Cambridge, we have quantified the divergence of human proteins at long, median and short evolutionary distances and compared the evolution of different biological process and functions. We have also collaborated with the Evolutionary Genomics Unit of the UPF in the study of chromosomal rearrangements and genic evolution in humans and chimpazees.

Resources

EVOLVABILITY. Human Genome Evolution of molecular Functions and Process

Selected Publications

Nuria Lopez-Bigas, Subhajyoti De & Sarah A. Teichmann. Functional divergence in the evolution of Homo sapiens. Genome Biology, 9(2):33 (2008).

Subhajyoti De, Nuria Lopez-Bigas and Sarah A Teichmann. Patterns of evolutionary constraints on genes in humans

BMC Evolutionary Biology. 8:275, (2008).

Marques-Bonet T , Sanchez-Ruiz J, Armengol L, Khaja R , Bertranpetit J, Rocchi M, Gazave E, Lopez-Bigas N, Navarro A. On the association between chromosomal rearrangements and genic evolution in humans and chimpanzees. Genome Biology , 8(10) (2007).