FannsDB 1.0-dev

FannsDB

FannsDB is a database for Functional ANnotations for Non Synonymous SNVs which contains precalculated scores for several predictors.

Condel

Condel is a method to assess the outcome of non-synonymous SNVs using a CONsensus DELeteriousness score that combines various tools (MutationAssessor, FATHMM). This is the second version of Condel which includes an update of the combined tools and a new web interface. If you use Condel, please cite us:

Improving the Assessment of the Outcome of Nonsynonymous SNVs with a Consensus Deleteriousness Score, Condel (2011)  Abel González-Pérez and Nuria López-Bigas, American Journal of Human Genetics 10.1016/j.ajhg.2011.03.004  Download PDF

The previous version will be available until the end of April 2014 at this url. Currently we do not plan to provide a RESTful web service but instead we will distribute the whole database as a tab separated text file (coming soon).

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TransFIC

TransFIC (TRANSformed Functional Impact for Cancer) is a method to transform Functional Impact scores taking into account the differences in basal tolerance to germline SNVs of genes that belong to different functional classes. This transformation allows to use the scores provided by well-known tools (e.g. SIFT, Polyphen2, MutationAssessor) to rank the functional impact of cancer somatic mutations. Mutations with greater TransFIC are more likely to be cancer drivers. If you use TransFIC, please cite us:

Improving the prediction of the functional impact of cancer mutations by baseline tolerance transformation (2012)  Gonzalez-Perez A, Deu-Pons J and Lopez-Bigas N. Genome Medicine. 4:89 doi:10.1186/gm390s  Read

We are working in a new version of the TransFIC scores and we will publish them here very soon. Meanwhile the original version is available at this url.

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