Our research explained in a short video

The University Pompeu Fabra has produced a video in which we explain in brief our research. We recorded three versions of the video, one in Catalan, one in Spanish and one in English. The videos are distributed through the UPF youtube channel.

I leave you here with the English version of the video. For the Catalan version follow this link. And this link for the Spanish version.


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My slides on: Identification of cancer drivers across tumor types

Yesterday I gave a talk at the PRBB Computational Genomics Seminars Series. In that talk I summarized our work of this year in the lab. Basically, we have developed methods to identify cancer driver genes and we have applied them to thousands of tumor resequenced genomes. Here, I leave you the slides, and I summarize the talk below.


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Comprehensive identification of mutational cancer driver genes across 12 tumor types

The Cancer Genome Atlas (TCGA) is an initiative supported by the National Cancer Institute and the National Human Genome Research Institute. Its immediate aim is to obtain a catalog of the molecular changes that occur in hundreds of tumors from the more common cancers in population. One year ago, the Pan-Cancer analysis group was formed within the TCGA, with the goal of analyzing alterations surveyed across several cancer types with an integrative approach. The rationale was that such across tumor types integrative analysis would provide insights to the process of tumorigenesis that could not be obtained from the analysis of each dataset separately. As explained in a previous post, we have had the opportunity to participate in this exciting project, whose marker paper has been recently published in Nature Genetics. On detail, our role was to analyze the mutations of the Pan-Cancer data set to identify genes that drive tumorigenesis in one or more of these cancer types. The results of this analysis have been published today in Nature Scientific Reports.