Condel in the world of web services

We have found two major drawbacks to computational approaches that assess the outcome of non-synonymous SNVs. The first is that there are now too many of them, based on different principles –some using phenomenological scoring functions, some that take advantage of machine learning strategies– but few efforts to make them comparable and integrate their outputs into a consensus that may be readily interpreted and employed by researchers. Our group and others have taken a first step towards the development of approaches to make such consensus possible. We recently developed and presented an approach to compute a Consensus Deleteriousness score (condel) of these computational tools and tested it with five of them. Read the rest of this entry »

July 28, 2011 | | Posted in: BG News | Comments Closed